Synthesis, Spectroscopic Characterization, and Biological Applications of Sulfamethoxazole Metal Complexes Bioinorganic and Molecular Docking Studies
Main Article Content
Abstract
Sulfamethoxazole complexes of [Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II)] were characterized using IR, UV-Vis, ESR, magnetic susceptibility, IR measurements revealed that sulfamethoxazole coordinates with metal ions as a bidentate ligand with stochiometries 1:2 (M:L). Electronic absorption spectra obtained using magnetic moment values revealed that all sulfamethoxazole compounds have octahedral geometry. The estimated room temperature powdered ESR data for the copper sulfamethoxazole complex with the formula is revealed to anisotropic spectra. Antimicrobial activities were screened for some metal complexes of sulfamethoxazole. Molecular docking studies of complexes against 3s7s protein as anti-breast cancer.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
How to Cite
References
"Sulfamethoxazole". DrugBank. Retrieved 5 November 2015.
Kanagaraj G. and Rao G.N., Synthesis and characterization of sohe first raw transition metal complexes of 4-amino-N-(5-methyl-3-1soxazolyl)-benzenesulfonamide (sulfamethoxazole), synth. react. inorg. met. - org. chem., 22(5), 559-574 (1992)
Vogel A.I, A Text Book of Quantitative Inorganic Analysis, Longmans, London, (1989) 722-726.
Ferreira I. C., Baptista P., , Vilas-Boas M. and Barros L. (2007). Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: Individual cap and stipe activity. Food chemistry, 100, 1511-1516.
Kolkaila S.A. , Ali A.E. and Elasala G.S., Synthesis, Spectral Characterization of Azithromycin with Transition Metals and a Molecular Approach for Azithromycin with Zinc for COVID-19. Int J Cur Res Rev. (2021)13, 23, 53-59.
Masoud M.S., Ali A.E., Elasala G.S. and kolkaila S.A., Synthesis, spectroscopic, biological activity and thermal characterization of ceftazidime with transition metals. Spectrochim. Acta. (2018) 193, 458-466.
Ali A. E. , Elasala G. S., Mohamed E. A. and kolkaila S.A., Spectral, thermal studies and biological activity of pyrazinamide complexes heliyon, (2019) 5(11)
Ali A.E., Elasala G.S., Mohamed E. A. and kolkaila S.A.,Structural and thermal analysis of some imipramine complexes. J. materials today proceeding.
Masoud M.S., Ali A.E., Elasala G.S. and kolkaila S.A., Synthesis, Spectroscopic Studies and Thermal Analysis on Cefoperazone Metal Complexes. J. Chem. Pharm. Res. (2017)9(4), 171-179.
Masoud M.S., Ali A.E., Elasala S. G., S.F sakr, kolkaila S.A.,Structural, Physicochemical Studies of Some Biologically Active Metal Complexes of Cefazolin Antibiotics J. Chem. Pharm. Res. (2020) 12, 42-52.
Kolkaila S.A. , Ali A.E.,Doha Beltagy and Elasala G.S., Spectral and Biological Studies of Some Selected Thiouracil, Barbital and Thiobarbituric Acid Complexes. J Drug Des.Res. (2018) 5, 2, 1071-1079.
Ali A. E.Elmelegy E. , Kolkaila S. A., Mustafa A. A., Eledkawy A. M. and Alnaggar G. A. Removal of Cadmium (II) from Water by Adsorption on Natural Compound. Journal of Environmental Treatment Techniques, (2022) 10(2) 164-169.
Kolkaila S.A. , Ali A.E. , Mustafa Ahmed A. Removal of Aluminum (III) from Water by Adsorption on the Surface of Natural Compound. J. of Environmental Treatment Techniques2023. (2023) 11(2) 10-105.
Ali A.E., Elasala G.S., Rana M.Atta. and kolkaila S.A., Synthesis, Thermal Analysis and Characterization of Doxycycline Metal Complexeschemistry research journal. (2022) 7,2,90-91
Ali A. E., Elasala G. S., Eldeeb M. H., kolkaila S. A. Synthesis and Biological Activity and Thermal Analysis of Sulfaquinoxaline Mixed Metal Complexes. Journal of Chemistry & its Applications. (2022) SRC/JCIA-119.DOI: doi.org/10.47363/JCIA/2023(2)119
Ali A. E., Elasala G. S., Eldeeb M. H., kolkaila S. A. Synthesis and Biological Activity and Thermal Analysis of Sulfaquinoxaline Mixed Metal Complexes. Journal of Chemistry & its Applications. (2022) SRC/JCIA-119.DOI: doi.org/10.47363/JCIA/2023(2)119
El-Tabl, A. S., El-Wahed, M. M. A. ., El Kadi, N. M., Kolkaila, S. A., & Samy, M.. Novel Metal Complexes of Bioactive Amide Ligands as New Potential Antibreast Cancer Agents. TWIST, (2023)18(4), 151-169.
El-Tabl, A. S., Kolkaila, S. A., Abdullah, S. M., & Ashour, A. M.. Nano-Organometallic Compounds as Prospective Metal BasedAnti-Lung Cancer Drugs: Biochemical and Molecular Docking Studies. TWIST, (2023) 18(4), 141-150.
El-Tabl, A. S., Dawood , A. A. E. R. ., Kolkaila , S.A., Mohamed , E. H., & Ashour, A.. The Cytotoxicity of Some Biologically Active Nano Compounds against Colon Cancer: Advanced Biochemical Analyses. TWIST, (2023) 18(4), 360-371.
El-Tabl, A. S., Abd El-Wahed, M. M., Kolkaila, S. A., Abd El-Nasser, A. G., & Ashour, A. M.. Biochemical Studies on Some Novel Organometallic Complexes as Anti-Human Prostate Cancer. TWIST,(2024) 19(1),16-26
Mohamed, E. A., Ali, A. E., Kolkaila, S. A., Fyala, S. S., & Elasala, G. S. (2024). Synthesis, Spectroscopic Studies, Thermal Analysis and Molecular Docking of Chloramphenicol Metal Complexes as Anti-Prostate Cancer. TWIST, 19(1), 400-408.