Synthesis, Spectroscopic Characterization, and Biological Applications of Some Metal Complexes Biochemical and Molecular Docking Studies
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Abstract
The solid complexes formed from N, N'-(1,2-phenylene) bis-(3,4,5-trihydroxybenzamide) bio active ligand (HL) expected to be potent anti-inflammatory and Mn(II), Fe(III), Ni(II), Cu(II) and Zn(II) have been synthesized and characterized by elemental and thermal analysis along with different spectroscopic techniques. The cytotoxic activity of some solid complexes against experimental animals (Albino rats) prostate cell cancer was extensively studied and expressed as lethal dose 50 (LD50). The acute intra-peritoneal toxicity of the chosen complexes was done using 21 experimental rat animals. After administration of the chosen complexes' concentrations, the rats were observed for toxic effects after 24h of treatment. Molecular docking studies against prostate cancer cell line (PC-3) had been done and compared to the practical data obtained.
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