Molecular Genetic Features of Congenital Angiodysplasias of the Brain in Patients with Cephalgic Syndrome

Abstract

The lack of awareness of many specialists in a narrow circle complicates the problem, since erroneous diagnosis and incorrect management of patients with cephalgic syndrome can lead to aggravation of their condition, on the one hand, and an increase in cases of serious complications. Aim of the study is evaluation of molecular genetic aspects of cerebral vascular abnormalities, we conducted a molecular genetic analysis of the VEGFA and MMP 3 genes. Research methods were study the role of these genes in the development of vascular anomalies, we first carefully assessed the prognostic effectiveness of the studied markers. The results of the work are based on data from a DNA study of 178 patients, who were divided into three subgroups: 92 (51.7%) patients had MSA; 41 (23.0%) were MBA, 45 (25.3%) were with DESA. A group of 172 healthy volunteers of Uzbek nationality was examined as a control. Study results have shown that P polymorphism C 634 G of the VEGF gene has 3 genotypic variants: C / C, C / G and G / G. Genotype 634 C / C is wild - major, G / G minor, and is relatively rare in the population. We can conclude that the polymorphic marker 5a/6a of the MMP3 gene plays a significant role in the formation of cerebral vascular abnormalities with the development of migraine and dyscirculatory encephalopathy.